Niagen®, a patented form of nicotinamide riboside (NR), is a NAD+ precursor that has gained popularity for its potential to support mitochondrial health, cellular repair, and healthy aging. When administered via IV or injection, Niagen bypasses the digestive system for rapid and efficient absorption, allowing for more immediate elevation of intracellular NAD+ levels. This can lead to enhanced energy production, improved cognitive function, metabolic support, and resilience against oxidative stress. IV and injectable forms of NR are often used in biohacking and integrative medicine protocols for patients seeking to optimize longevity, athletic recovery, or post-illness cellular regeneration. While oral NR supplements can be effective, IV and injectable delivery offers higher bioavailability and more pronounced therapeutic effects in clinical settings.

Nicotinamide Riboside (NR)

  • NR vs NAD+

    NAD+ (nicotinamide adenine dinucleotide) and NR (nicotinamide riboside) are closely related but functionally distinct. NAD+ is the active coenzyme used directly in cellular energy production, DNA repair, and metabolic signaling. However, due to its size and structure, NAD+ is not well absorbed orally, making IV delivery the most effective method. NR, on the other hand, is a precursor to NAD+—a form of vitamin B3 that converts into NAD+ once inside the cell. NR is more stable for oral or injectable use and can help gradually elevate NAD+ levels over time. While both support mitochondrial health and healthy aging, NAD+ offers immediate cellular support when delivered intravenously, whereas NR is a powerful tool for sustaining and rebuilding NAD+ stores through supplementation.

  • IV vs Injection

    IV, injection, and oral supplementation, the key differences lie in absorption rate, bioavailability, and therapeutic impact. IV (intravenous) administration delivers nutrients directly into the bloodstream, bypassing the digestive system entirely and allowing for 100% bioavailability—ideal for rapid repletion and high-dose therapies. Intramuscular or subcutaneous injections also bypass the gut and offer a slower, more sustained release compared to IV, making them suitable for ongoing maintenance or targeted support. Oral often delivers only a fraction of the intended dose, especially in individuals with gut or metabolic issues. For patients seeking more intensive, immediate, or measurable outcomes, IV and injection therapies are often preferred.

  • Benefits

    Nicotinamide riboside (NR) is a powerful NAD+ precursor known for its ability to support cellular energy production, mitochondrial function, and healthy aging. By boosting NAD+ levels, NR helps enhance metabolism, improve cognitive performance, support cardiovascular health, and promote DNA repair and cellular resilience. It has shown promise in reducing fatigue, supporting muscle recovery, and protecting against age-related decline. NR is especially beneficial for individuals experiencing high levels of stress, inflammation, or metabolic dysfunction, offering a proactive way to support long-term vitality and cellular regeneration.

Book Here

NR Protocol

Due to the lack of side effects one might typically experience with NAD+ we introduce NR at 500 mg. This is a good starting point for most, and we see more noticeable difference at this dosage.

Infusion Time:

  • Over 45–90 minutes, depending on patient tolerance (can be adjusted to slower rates for first-time users or those with sensitivity to NAD+ precursors)

Frequency:

  • Therapeutic phase: 2–3 times per week for 2–4 weeks

  • Maintenance: 1–2 times per month

  • Stacking option: May alternate or cycle with NAD+ IVs, or be paired with mitochondrial co-factors (e.g., glutathione, B vitamins, carnitine, CoQ10)