NAD⁺ (nicotinamide adenine dinucleotide) is a powerful coenzyme found in every cell of the body, essential for energy production, DNA repair, and cellular regeneration. As we age, NAD⁺ levels naturally decline, contributing to fatigue, brain fog, slower metabolism, and signs of aging. Supplementing with NAD⁺—particularly through IV therapy—has gained popularity for its ability to enhance mitochondrial function, boost energy, improve mental clarity, support detoxification, reduce pain and inflammation, and promote healthy aging at the cellular level. It's become especially sought after in the wellness and biohacking communities for its potential to optimize performance, recovery, and longevity. Whether you're recovering from illness, managing chronic stress, or simply looking to feel more energized and focused, NAD⁺ can be a game-changer.
NAD+
Temporary Side Effects
Some individuals may experience brief, temporary sensations during or shortly after a NAD+ treatment—such as mild sinus pressure, a fluttery or racing heartbeat, or slight gastrointestinal discomfort. These responses typically occur within the first 15 minutes of an injection or during the infusion itself and resolve quickly on their own. They’re often a sign that the NAD+ is being rapidly utilized, especially in areas of inflammation or increased cellular demand. In fact, some providers use this response pattern as a diagnostic indicator. As your NAD+ levels become replenished over time, these sensations usually diminish significantly or disappear altogether.
IV vs Injection
IV therapy delivers nutrients directly into the bloodstream, allowing for higher volumes, immediate absorption, and full-body support—making it ideal for hydration, energy restoration, immune balance, and recovery. Injections, by contrast, are quick intramuscular or subcutaneous doses that provide a concentrated, targeted hit of specific nutrients such as B12 for energy, MIC for metabolism, or glutathione for detoxification. Both methods are effective; the best choice depends on your goals, schedule, and the level of support your system needs. This distinction is especially relevant with therapies like NAD+, where IV delivery allows for deeper systemic impact, while injections offer faster, more focused dosing. We only recommend you schedule plenty of time for your first experience.
Benefits
Patients often report a noticeable lift in energy, mental clarity, mood, and overall vitality after NAD⁺ therapy. Many experience sharper focus, more restorative sleep, enhanced metabolic function, and a reduction in inflammation within hours to a few days of their session. These effects can last from several days to a few weeks, depending on each person’s baseline. One of the most powerful aspects of NAD⁺ is its compounding nature—consistent treatments help your cells repair, regenerate, and operate more efficiently. Over time, patients commonly see their baseline energy, resilience, and cognitive performance rise to new, sustained levels.
NAD+ Uses
-
-
Role of NAD+ in regulating cellular and metabolic signaling pathways
NAD+ metabolism and its roles in cellular processes during ageing
NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy
Effects of NAD+ precursor supplementation on glucose and lipid metabolism in humans: a meta-analysis
-
-
-
Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder
Nicotinamide Riboside—The Current State of Research and Therapeutic Uses
-
-
-
NAD+ Protocol
Dr. Craig Koniver, founder of Koniver Wellness, developed a highly respected NAD⁺ protocol that delivers a total of 750 mg of NAD⁺ over 10 days, typically divided into smaller doses administered across multiple sessions. This loading phase is designed to gently saturate the body with NAD⁺ without overwhelming the system, allowing for improved cellular uptake and fewer temporary responses. His clinic has observed profound results, including enhanced energy, improved mental clarity, reduced anxiety, better sleep, and faster recovery from burnout or chronic fatigue. With ongoing monthly maintenance sessions, these benefits often compound over time, supporting mitochondrial repair, hormone regulation, detoxification, and graceful aging. Dr. Koniver’s approach highlights NAD⁺ as not just a performance tool, but a foundational therapy for long-term cellular health and resilience.
At the end of each NAD⁺ infusion, a nutritional IV to further enhance absorption and therapeutic impact.
Once the loading dose is complete, patients move to a monthly maintenance dose of NAD+ and are seeing dramatic improvements physically.
Clinically, over 95% of patients respond positively, with substantial benefits in mitochondrial renewal, DNA repair, and resistance to age-related decline and chronic disease.
We’ve adopted a similar protocol in the form of memberships and our members are seeing remarkable benefits.
NAD+ Memberships
NAD+ Maintenance Membership
most popular
Starts out with a loading dose of 750 mg via IV that you can divide over 10 days. Then moves to two monthly 100 mg injections. One of our most popular memberships. 10%-15% off additional services.
NAD+ Powerhouse Membership
Our recommended protocol for those who have chronically low energy, history of EBV, want to improve athletic performance. Starts with a loading dose of 750 mg via IV given within 10 days. Then 500 mg IV once a month. 10%-15% discount on additional services.