Peptide Stacks for Metabolic Health & Weight Loss

The New Hack For Restoring Your Body’s Healthy Signaling

Metabolic dysfunction is at the root of many modern health challenges, from stubborn abdominal fat and insulin resistance to low energy and difficulty maintaining a healthy weight. While lifestyle changes remain the cornerstone of long-term metabolic health, research into peptide therapy offers exciting adjunctive strategies. Unlike synthetic stimulants or quick fixes, peptides work by signaling the body to restore natural processes such as fat mobilization, mitochondrial function, and hormone balance.

Below, we’ll explore several cutting-edge peptides—MOTS-c, CJC-1295, AOD-9604, SLU-pp-332, and 5-Amino-1MQ—and how they may be combined into synergistic stacks for improved metabolic health.

MOTS-c: The Mitochondrial Peptide for Energy & Insulin Sensitivity

MOTS-c is a mitochondrial-derived peptide that plays a direct role in regulating cellular energy and metabolism. Research suggests it:

• Increases insulin sensitivity, supporting better blood sugar regulation.

• Enhances fat oxidation and utilization of glucose during exercise.

• Promotes mitochondrial biogenesis, improving energy efficiency.

Best Use: MOTS-c is often cycled in 2–4 week blocks, used to improve energy, stamina, and support weight loss in those with metabolic sluggishness.

CJC-1295: Growth Hormone-Releasing Peptide for Lean Mass & Fat Loss

CJC-1295 (often paired with Ipamorelin) is a growth hormone secretagogue that stimulates the natural release of growth hormone (GH) and IGF-1. Its metabolic benefits include:

• Increasing lean muscle mass, which drives long-term fat burning.

• Enhancing lipolysis (fat breakdown), especially in the abdominal region.

• Improving recovery and sleep quality, both essential for metabolic health.

Best Use: Stacked with MOTS-c or AOD-9604, CJC-1295 helps create a favorable body composition shift—more muscle, less fat.

AOD-9604: Fat-Specific Fragment of Growth Hormone

Unlike GH itself, AOD-9604 is a fragment designed to stimulate fat breakdown without affecting blood sugar or growth pathways. Research has shown it:

• Targets stubborn fat deposits, particularly abdominal and visceral fat.

• Increases fatty acid oxidation and energy expenditure.

• May improve lipid metabolism without the risks of full GH therapy.

Best Use: Works synergistically with CJC-1295 for abdominal fat reduction and with MOTS-c for improved fat-to-energy conversion.

SLU-pp-332: The New AMPK Activator

SLU-pp-332 is an emerging peptide that mimics AMPK activation, sometimes described as “exercise in a molecule.” AMPK is the master regulator of energy balance in cells. Early findings suggest SLU-pp-332 may:

• Enhance fatty acid metabolism and glucose uptake.

• Reduce hepatic fat accumulation (supporting liver health).

• Improve exercise tolerance and endurance.

Best Use: Best paired with MOTS-c for mitochondrial health and AOD-9604 for fat-specific targeting, offering both systemic and localized fat loss benefits.

5-Amino-1MQ: The NNMT Inhibitor for Fat Reduction

5-Amino-1MQ is a small molecule peptide-like compound that inhibits nicotinamide N-methyltransferase (NNMT), an enzyme linked to fat storage and metabolic slowdown. Research suggests:

• Promotes loss of fat mass, especially visceral fat.

• Enhances NAD+ availability, supporting energy metabolism and longevity.

• Improves insulin sensitivity and metabolic rate.

Best Use: Complements mitochondrial peptides (like MOTS-c) and fat-burning peptides (like AOD-9604) for a full-spectrum approach to fat loss and metabolic regulation.

While these peptides show tremendous promise, most are still considered research compounds. This is why safety, dosing, and cycles should be guided by are guided by our team of clinicians. Lifestyle—nutrition, sleep, stress management, and exercise—remains the foundation. Peptides should be seen as enhancers, not replacements.

Bottom Line:
Peptide therapy offers an innovative path to restoring metabolic flexibility, improving body composition, and supporting long-term health. By stacking targeted peptides such as MOTS-c, CJC-1295, AOD-9604, SLU-pp-332, and 5-Amino-1MQ, practitioners can create synergistic protocols that address energy, insulin sensitivity, and fat metabolism from multiple angles.

Check out our metabolic peptide stacks available at The Wellness Lounge!